ACCENT (SIBUTRAMINE) 10M BY MACTER PHARMA / PACK

Product Details: Accent (Sibutramine) 10mg by Macter Pharma x 1 Pack (14 Capsules)

Composition: Each Capsule contains Sibutramine hydrochloride monohydrate 10 & 15mg

Prescribing Information: Accent belongs to Sibutramine class which is a weight reducer. Sibutramine is a neurotransmitter reuptake inhibitor that inhibits the reuptake serotonin (by 73%), norepinephrine (by 54%). It helps enhance Satiety. Sibutramine is well absorbed from the GI-Tract (77%), Undergoes a first-pass metabolism reducing its bioavailability. It reaches its peak plasma level after 1 hour. Is metabolized by cytochrome-P450-isoenzyme resulting in 2 active primary and secondary amines (called active metabolites 1 and 2). Peak plasma concentrations of active metabolites 1 and 2 are reached after 3 to 4 hours. Accent is excreted 85% in urine and 15%faeces. Although predominantly inactive metabolites are excreted by the renal route, caution is recommended when treating patients with reduced renal function. Initial dosage is 10mg once daily. In patients with inadequate response to Accent (Sibutramine) at 10mg the dose may be increased to 15mg once daily.

Accent Sibutramine 10mg by Macter Pharma x 1 Pack

Hepatic Insufficiency

In patients with moderate hepatic impairment receiving a single 15 mg oral dose of Nobese, the combined AUCs of M1 and M2 increased by 24% which does not warrant dose adjustment.

Renal Insufficiency

Illumination of inactive hydroxyl metabolites, which are renally excreted, may be affected in this population.

Indications

• Nobese is indicated for management of obesity including weight loss and weight maintenance When used in conjunction with a reduce calorie diet.
• In patients with an initial body mass index <30kg/m or <27kg/m in the presence of oter risk factors (hypertension, disbetes, dislipidemia).

Dosage

The recommended initial oral dose of nobese is 10 mg capsule once daily with or without food. If there is inadequate weight loss (i.e. <20kg) the dose may be increased to 15 mg provided 10 mg was well tolerated. The 5 mg dose should be reserved for patients who do not tolerate the 10 mg dose. Accent Sibutramine 10mg by Macter Pharma x 1 Pack